A demonstration showing how biclusters of coregulated genes in Halobacterium can be projected onto Pyrococcus using Gaggle.
In this demo, we show how to view the regulatory network for Halobacterium produced by the cMonkey and Inferelator algorithms. A helper application shows expression profiles, regulatory motifs, and protein-protein interactions for each bicluster. In order to investigate conservation of these features, we choose a bicluster in Halobacterium and look up orthologous genes in Pyrococcus. Finally, we display interactions among the selected Pyrococcus orthologs.Here are the links to start each of the relevant Gaggle tools (numbered by the corresponding step in the tutorial).